The outbreak of the unsuccessful revolt of 1821 in Macedonia, in which the Xenofontos monk Gedeon was actively involved, lead to the halt of the important construction projects in progress at the Monastery, while after the defeat of the rebels, the Monastery paid a heavy price: At least four monks – Chrysanthos, Neofytis, Isaak and Xenofon – were martyred. Ottoman soldiers occupied the Monastery, forcing the majority of fathers to abandon it and to seek refuge in Skopelos, taking with them the heirlooms of the Monastery.
