An important part in the history of the Monastery was played by the Metropolite Samakovios Filotheos of Lesbos, whose presence at the Monastery after his resignation from the throne in 1819 is connected with his obtaining economic support for the construction of the new cathedral in a variety of ways. In 1821, Filotheos was among the Xenofontian fathers who ‘took to the road’ after being forced to relocate to the metochi of the Monastery on Skopelos. He died there either that same year, or the one following.
It likely that the scholarly monk Theoklitos Karatzas the Byzantine resided in the Monastery. A descendant of the well-known family of Konstantinople, he was mainly known for the collection of legal canons he wrote. His works are contained in a number of manuscripts, two of which are at the Xenofontos Monastery.
